Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
5 years ago

Significant Acceleration of Acylative Kinetic Resolution of Racemic Diols

Significant Acceleration of Acylative Kinetic Resolution of Racemic Diols
Seiji Suga, Koichi Mitsudo, Hiroki Mandai, Kazuki Fujii
The front cover image, provided by Kazuki Fujii, Hiroki Mandai, and Seiji Suga, illustrates the large scale (10 g) kinetic resolution of d,l-hydrobenzoin with a highly active nucleophilic catalyst. The catalyst well recognizes the diol unit and accelerates only the monoacylation reaction. The reaction proceeds with only 0.1 mol% of the catalyst within 30 min, and both the monoacylate and the recovered diol are obtained with high enantioselectivities. The acceleration effect by the catalyst is portrayed by the tachometer in the picture. Details can be found in the full paper on pages XXXX-XXXX (K. Fujii, K. Mitsudo, H. Mandai, S. Suga, Adv. Synth. Catal. 2017, 359, XXXX-XXXX; DOI: 10.1002/adsc.201700057).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700620

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