3 years ago

Guanidinium Hydroiodide/Cumene Hydroperoxide-Mediated Intermolecular Oxidative Coupling Reaction of β–Ketoamides with Oxindoles

Guanidinium Hydroiodide/Cumene Hydroperoxide-Mediated Intermolecular Oxidative Coupling Reaction of β–Ketoamides with Oxindoles
Koji Yasui, Takanari Kato, Kazuo Nagasawa, Minami Odagi
The first catalytic intermolecular oxidative cross-coupling reaction between two different carbonyl compounds was achieved by using cumene hydroperoxide as an environmentally friendly, mild oxidant in the presence of a cyclic guanidinium hydroiodide derivative as a catalyst. Cross-coupling reaction between variouβ ketoamides and oxindoles took place smoothly, and the corresponding 1,4-dicarbonyl compounds were obtained in 80–99% yield.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700266

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