During the last decade, extracellular vesicles (EVs), produced by most cell types, have been envisaged as reservoirs of biomarkers for diagnosis, and as drug and gene delivery carriers for cell-free therapeutic approaches.
In the second event of this series, we will hear about the potential of EV content as a source of information on diseased conditions. Join us and find out more about it with Dr Van Keuren-Jensen.
We have looked at the transcriptomic profile of several different biofluids for their tissue-enriched contents. One area of research that we are particularly focused on is monitoring the exRNAs potentially associated with CNS tissues. A characterization of the types of exRNAs in different biofluids will be presented. We will discuss both small and long RNA transcriptomes. Improvements on how to get brain-derived information will also be presented.
Event series program:
- Monday 28th November 3pm GMT: Studying tetraspanins in extracellular vesicles with Dr María Yañez-Mo, Autonomous University of Madrid
- Wednesday 30th November, 5.30pm GMT: Assessment of exRNAs for monitoring CNS related injury and disease with Dr Kendall Van Keuren Jensen, from the Translational Genomics Research Institute (Phoenix)
- Thursday 1st December 3pm GMT: Therapeutic potential of extracellular vesicles together with Dr Marta Moguió-Tortajada, Germans Trias i Pujol Research Institute
- Monday 5th December, 2pm GMT: Pharmacokinetics and biodistribution of extracellular vesicles after intravenous and intranasal administration in macaques with Dr Tom Driedonks, UMC Utrecht
05:30 pm - 06:30 pm GMT+0
Dr Van Keuren-Jensen received her Ph.D. from Stonybrook University in New York, at Cold Spring Harbor Laboratory. After a short postdoctoral fellowship at Harvard University, she joined TGen, the Translational Genomics Research Institute in Phoenix. Currently, she is a TGen Deputy Director, Professor in the Neurogenomics Division, and Director of the Center for Non-Invasive Diagnostics. Her lab is interested in understanding injury and disease in the central nervous system (CNS). Due to the difficulty to access this very protected area, her research efforts focus on the study of extracellular RNAs (exRNAs) in peripheral circulation as promising tools for monitoring the CNS, providing information about cellular changes occurring in different tissues. In this sense, extracellular vesicles and exosomes confer a protected environment for biomolecules, which makes them an attractive and promising source of disease biomarkers.
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