Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
5 years ago

Copper-Catalyzed Intermolecular Aminoalkylation of Alkenes with α-Bromoalkyl Esters and Amines toward Pyrrolidin-2-ones

Copper-Catalyzed Intermolecular Aminoalkylation of Alkenes with α-Bromoalkyl Esters and Amines toward Pyrrolidin-2-ones
Gao-Hui Pan, Jin-Heng Li, Ye-Xiang Xie, Ming Hu, Xuan-Hui Ouyang
We here describe a new copper-catalyzed tandem annulation of alkenes with α-bromoalkyl esters and primary amines for producing polysubstituted pyrrolidin-2-ones. The reaction allows the formation of three new chemical bonds, one C–C bond and two C–N bonds, in a single reaction, and represents the first three-component difunctionalization of alkenes for the synthesis of pyrrolidin-2-ones involving [2+2+1] annulation.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700365

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