3 years ago

Copper-Catalyzed Intermolecular Aminoalkylation of Alkenes with α-Bromoalkyl Esters and Amines toward Pyrrolidin-2-ones

Copper-Catalyzed Intermolecular Aminoalkylation of Alkenes with α-Bromoalkyl Esters and Amines toward Pyrrolidin-2-ones
Gao-Hui Pan, Jin-Heng Li, Ye-Xiang Xie, Ming Hu, Xuan-Hui Ouyang
We here describe a new copper-catalyzed tandem annulation of alkenes with α-bromoalkyl esters and primary amines for producing polysubstituted pyrrolidin-2-ones. The reaction allows the formation of three new chemical bonds, one C–C bond and two C–N bonds, in a single reaction, and represents the first three-component difunctionalization of alkenes for the synthesis of pyrrolidin-2-ones involving [2+2+1] annulation.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700365

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.