Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
5 years ago

A Polystyrene-Supported Phase-Transfer Catalyst for Asymmetric Michael Addition of Glycine-Derived Imines to α,β-Unsaturated Ketones

A Polystyrene-Supported Phase-Transfer Catalyst for Asymmetric Michael Addition of Glycine-Derived Imines to α,β-Unsaturated Ketones
Shū Kobayashi, Hiroyuki Miyamura, Javier Miguélez
The front cover picture, provided by Shū Kobayashi and co-workers, illustrates a polymer immobilized chiral 2-oxopyrimidinium salt for asymmetric Michael addition of glycine-derived imines to α,β-unsaturated ketones. The reaction proceeded smoothly with 5 mol % of the heterogeneous catalyst and the products were obtained with good to excellent enantioselectivities. Interestingly, the addition of polydimethylsilane to the chiral heterogeneous catalyst greatly improved the ease of handling of the catalyst and the thus prepared composite catalyst could be recovered and reused several times, keeping activity and enantioselectivity. Details can be found in the communication on pages XXXX–XXXX (J. Miguélez, H. Miyamura, S. Kobayashi, Adv. Synth. Catal. 2017, 359, XXXX–XXXX; DOI 10.1002/adsc.201700155).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700625

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