Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
5 years ago

Front Cover Picture: cis-4-Alkoxydialkyl- and cis-4-Alkoxydiarylprolinol Organocatalysts: High Throughput Experimentation (HTE)-Based and Design of Experiments (DoE)-Guided Development of a Highly Enantioselective aza-Michael Addition of Cyclic Imides to α,β-Unsaturated Aldehydes (Adv. Synth. Catal. 14/2017)

Front Cover Picture: cis-4-Alkoxydialkyl- and cis-4-Alkoxydiarylprolinol Organocatalysts: High Throughput Experimentation (HTE)-Based and Design of Experiments (DoE)-Guided Development of a Highly Enantioselective aza-Michael Addition of Cyclic Imides to α,β-Unsaturated Aldehydes (Adv. Synth. Catal. 14/2017)
Miquel A. Pericàs, Fernando Bravo, Alessandro Ferrali, Carles Rodríguez-Escrich, Ismael Arenas
The front cover picture, provided by Miquel A. Pericàs and Fernando Bravo, illustrates the powerful combination of High Throughput Experimentation (HTE, that significantly speeds up catalyst selection) and Design of Experiments (DoE, that uses the best candidate as a bait to fish out the optimal reaction conditions). This process is exemplified in the not well resolved addition of nitrogen nucleophiles to enals. Details can be found in the full paper on pages 2414–2424 (I. Arenas, A. Ferrali, C. Rodríguez-Escrich, F. Bravo, M. A. Pericàs, Adv. Synth. Catal. 2017, 359, 2414–2424; DOI: 10.1002/adsc.201700120).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700610

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