3 years ago

Photoinduced Copper(I)-Catalyzed Cyanation of Aromatic Halides at Room Temperature

Photoinduced Copper(I)-Catalyzed Cyanation of Aromatic Halides at Room Temperature
Soon Hyeok Hong, Kicheol Kim
The first photoinduced copper(I)-catalyzed cyanation of aromatic halides at room temperature has been developed. The sp2 cyanation reaction exhibits outstanding tolerance to functional groups including primary amines and carboxylic acids, and chemoselectivity to SN2-reactive alkyl chlorides. Mechanistic investigations indicate that the reaction occurs via a single-electron transfer (SET) between the aryl halide and an excited copper(I) cyanide catalytic intermediate.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700213

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