3 years ago

An Enantioselective Multicomponent Carbonyl Allylation of Aldehydes with Dienes and Alkynyl Bromides Enabled by Chiral Palladium Phosphate

An Enantioselective Multicomponent Carbonyl Allylation of Aldehydes with Dienes and Alkynyl Bromides Enabled by Chiral Palladium Phosphate
Liu-Zhu Gong, Zhi-Yong Han, Pu-Sheng Wang, Zhong-Lin Tao, Hong-Cheng Shen
An enantioselective multicomponent carbonyl allylation reaction of 1,3-butadienes, alkynyl bromides and aldehydes has been established, leading to the generation of densely functionalized homoallylic alcohols in high levels of structural diversity and stereoselectivity. The multicomponent process sequentially comprises the oxidative addition, salt metathesis, insertion/π-allyl-Pd formation, asymmetric allylic borylation, and enantioslecitve carbonyl allylborylation, wherein the alkynyl palladium phosphate in situ generated from the chiral silver phosphate and the alkynyl palladium bromide turns out to be a key intermediate that allows the efficient stereochemical control.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700621

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.