3 years ago

Palladium-Catalyzed Direct β-C−H Arylation of Ketones with Arylboronic Acids in Water

Palladium-Catalyzed Direct β-C−H Arylation of Ketones with Arylboronic Acids in Water
Chao-Jun Li, Xiaoyun Hu, Xi-Jie Dai, Xiaobo Yang
A palladium-catalyzed direct β-C−H arylation of ketones was developed under mild conditions in water, featuring commercially available arylboronic acids as nucleophilic aryl sources and o-iodoxybenzoic acid as the oxidant. The method provides a concise route to access β-arylated ketones. Preliminary studies indicated that direct asymmetric β-C−H arylation of ketones could be achieved by this strategy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700277

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.