Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
5 years ago

Palladium-Catalyzed Direct β-C−H Arylation of Ketones with Arylboronic Acids in Water

Palladium-Catalyzed Direct β-C−H Arylation of Ketones with Arylboronic Acids in Water
Chao-Jun Li, Xiaoyun Hu, Xi-Jie Dai, Xiaobo Yang
A palladium-catalyzed direct β-C−H arylation of ketones was developed under mild conditions in water, featuring commercially available arylboronic acids as nucleophilic aryl sources and o-iodoxybenzoic acid as the oxidant. The method provides a concise route to access β-arylated ketones. Preliminary studies indicated that direct asymmetric β-C−H arylation of ketones could be achieved by this strategy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700277

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