Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
4 years ago

Palladium-Catalyzed Synthesis of Tetrasubstituted Olefins by Triple Domino Process

Palladium-Catalyzed Synthesis of Tetrasubstituted Olefins by Triple Domino Process
Kanagaraj Naveen, Savariyappan Albert Nikson, Paramasivan Thirumalai Perumal
An efficient, highly regio- and stereoselective protocol for the synthesis of tetrasubstituted olefins was developed to take place by a palladium(0)-catalyzed triple domino process. It involves the formation of three new C−C bonds through double carbopalladation and C−H activation across 2-bromoaryl alkynyl biaryls/heteroaryls with norbornene. This method is practically simple with broad substrate scope and tolerates a wide range of substituents. The products bearing 9H-pyrrolo[1,2-a]indole motifs reveal intriguing solid state fluorescence properties and thus form a new class of aggregation induced emission (AIE) fluorophores.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700169

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