Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis
5 years ago

Palladium-Catalyzed Regioselective Direct Arylation of Benzofurazans at the C-4 Position

Palladium-Catalyzed Regioselective Direct Arylation of Benzofurazans at the C-4 Position
Jean-François Soulé, Henri Doucet, Fazia Derridj, Imane Idris
The palladium-catalyzed direct arylation of benzofurazans with aryl bromides to access 4-arylbenzofurazans proceeds in moderate-to-high yields using phosphine-free palladium acetate as the catalyst and potassium acetate as an inexpensive base. A wide variety of (hetero)aryl bromides, including bromopyridine and bromothiophene derivatives has been successfully employed. Palladium-catalyzed one-pot C-4,C-7-diarylation of benzofurazan was also achieved using a larger amount of aryl bromide. Moreover, the derivatization of 4-arylbenzofurazans into 4-arylquinaxolines is also reported.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adsc.201700435

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