3 years ago

Cobalt-Catalyzed Cross-Coupling of α-Bromo Amides with Grignard Reagents

Cobalt-Catalyzed Cross-Coupling of α-Bromo Amides with Grignard Reagents
A. Guérinot, E. Barde, J. Cossy
A cobalt-catalyzed cross-coupling between α-bromo amides and Grignard reagents is disclosed. The reaction is general and allows access to a large variety of α-aryl and β,γ-unsaturated amides. Some mechanistic investigations have been undertaken to determine the nature of the intermediate species.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02848

DOI: 10.1021/acs.orglett.7b02848

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