Organic Letters
Organic Letters
4 years ago

Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis

Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis
Zong-Feng Zhang, Dong-Xing Zhu, Bin Xu, Wen-Wen Chen, Ming-Hua Xu
An asymmetric dual-metal relay catalysis strategy that combines Rh/chiral sulfur-olefin-catalyzed enantioselective 1,2-addition with a Pd-catalyzed intramolecular C–O coupling has been developed. The method allows rapid and efficient synthesis of quaternary carbon-containing gem-diaryl benzofuran-3(2H)-ones in good yields in a highly enantioselective manner (up to 99% ee) through a simple one-pot cascade reaction.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01070

DOI: 10.1021/acs.orglett.7b01070

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