3 years ago

Sometimes It's Good to be Short: The Serotonin Transporter Gene, Positive Parenting, and Adolescent Depression

Sarah Whittle, Julian G. Simmons, Lisa B. Sheeber, Craig A. Olsson, Ann V. Sanson, George J. Youssef, Debra L. Foley, Keriann Little, Nicholas B. Allen, Jacqui A. Macdonald
In threatening environments, the short (S) allele of 5-HTTLPR is proposed to augment risk for depression. However, it is unknown whether 5-HTTLPR variation increases risk for depression in environments of deprivation, lacking positive or nurturant features. Two independent longitudinal studies (n = 681 and 176, respectively) examined whether 5-HTTLPR moderated associations between low levels of positive parenting at 11–13 years and subsequent depression at 17–19 years. In both studies only LL homozygous adolescents were at greater risk for depression with decreasing levels of positive parenting. Thus, while the S allele has previously been identified as a susceptible genotype, these findings suggest that the L allele may also confer sensitivity to depression in the face of specific environmental challenges.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/cdev.12987

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