3 years ago

In vivo behavior of hydroxyapatite/β-TCP/collagen scaffold in animal model. Histological, histomorphometrical, radiological, and SEM analysis at 15, 30, and 60 days

Rafael Arcesio Delgado Ruiz, Maria Piedad Ramírez Fernández, Jose Eduardo Maté Sánchez de Val, Patricia Mazón, Josè Luis Calvo Guirado, Piedad N. De Aza
Objective The aim of this study was to fabricate and characterize HA/β-TCP/collagen ceramic scaffolds of different composition ratios and compare their physical and In vivo mechanical behavior. Materials and methods Three groups of twenty samples each one of calcium–phosphate ceramic scaffold cylindrical implants (6 ± 0.01 mm in diameter and 2 ± 0.01 mm in length) were studied with varying wt % HA/wt % TCP/wt % Collagen composition: Group A: 40/30/30; Group B: 50/20/30; Group C: 60/20/20. A fourth group, Group D (unfilled critical size defect), acted as control. Three times of work were established 15, 30, and 60 days. Characterization, histological, histomorphometric, SEM, and radiological analysis were performed. Results Micrographs obtained on the different composites are comparable, it is possible observe that the materials revealed a microporous morphology formed by aggregated nanoparticles independently of the composition of the composite. BIC values for the three materials, with Group A showing best BIC at 15, 30, and 60 days (43.12 ± 0.14; 52.49 ± 1.08 and 67.23% ± 0.34) (with closer contact observed) than Group B (38.84 ± 1.32; 47.64 ± 1.21 and 54.87 ± 0.32), followed by Group C (28.92 ± 2.41; 35.94 ± 1.92 and 48.53 ± 0.31). Conclusions The influence of time on the biological behavior of biomaterials studied has been demonstrated by varying the percentage of bone–implant contact and bone formation to obtain the best results at 60 days.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/clr.12656

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