Journal of the American Chemical Society
Journal of the American Chemical Society
4 years ago

Flexible and Chemoselective Oxidation of Amides to α-Keto Amides and α-Hydroxy Amides

Flexible and Chemoselective Oxidation of Amides to α-Keto Amides and α-Hydroxy Amides
Daniel Kaiser, Aurélien de la Torre, Nuno Maulide
A suite of flexible and chemoselective methods for the transition-metal-free oxidation of amides to α-keto amides and α-hydroxy amides is presented. These highly valuable motifs are accessed in good to excellent yields and stereoselectivities with high functional group tolerance. The utility of the method is showcased by the formal synthesis of a potent histone deacetylase inhibitor.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b02983

DOI: 10.1021/jacs.7b02983

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