3 years ago

Cardiac Non-Human Leukocyte Antigen Identification: Techniques and Troubles.

Leigh G Griffiths, Katherine V Gates, Naveen L Pereira
Historically efforts have focused on the human leukocyte antigen (HLA) as the major cause for acute and chronic rejection following cardiac transplantation. However, rising evidence indicates that non-HLA antibodies can be both primary initiators and modifiers of antibody-mediated rejection (AMR) and cardiac allograft vasculopathy (CAV). The purpose of this review is to assess currently available technologies for non-HLA identification and leveraging such responses toward antibody quantification. Several techniques have been used to identify antigenic determinants of recipient graft-specific non-HLA humoral immune responses, but each comes with its own set of benefits and caveats. Improving our ability to detect non-HLA humoral immune response will aid in our understanding of the underlying antigenic determinants of AMR and CAV, as well as improve patient outcomes.

Publisher URL: http://doi.org/10.3389/fimmu.2017.01332

DOI: 10.3389/fimmu.2017.01332

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