3 years ago

Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions

Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions
Leticia González, Veronica Tona, Aurélien de la Torre, Josefine Sprachmann, Nuno Maulide, Boris Maryasin
Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting material and the mild conditions allow a broad functional group tolerance.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01004

DOI: 10.1021/acs.orglett.7b01004

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