3 years ago

An efficient, environmentally benign, and solvent-free protocol for the synthesis of 4-substituted 1,5-benzodiazepines catalyzed by reusable sulfated polyborate

An efficient, environmentally benign, and solvent-free protocol for the synthesis of 4-substituted 1,5-benzodiazepines catalyzed by reusable sulfated polyborate
An efficient and environmentally benign method has been developed for the one-pot solvent-free synthesis of 4-substituted-1,5-benzodiazepines via three-component reaction of o-phenylenediamine, dimedone with a variety of aldehydes catalyzed by sulfated polyborate. The major advantages of the present method are good to excellent yields, shorter reaction time, simple experimental procedure, easy workup, solvent-free reaction condition, recyclability of the catalyst and ability to tolerate a variety of functional groups which gives economical as well as ecological rewards.

Publisher URL: www.sciencedirect.com/science

DOI: S0040403917313102

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