3 years ago

Copper-catalyzed hydroamination of propargyl imidates

Copper-catalyzed hydroamination of propargyl imidates
Propargyl imidates derived from aromatic and aliphatic nitriles cyclize at room temperature in high yields when treated with a catalytic amount of copper (I) iodide. This 5-exo-dig process affords dihydrooxazoles which do not aromatize under the reaction conditions, and which are isolated without chromatography. Investigations of the reaction scope, subsequent functionalization of the reaction products, and preliminary mechanistic data are presented.

Publisher URL: www.sciencedirect.com/science

DOI: S0040403917313357

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