3 years ago

Dendritic poly(benzyl ether)-b-poly(N-vinylcaprolactam) block copolymers: Self-organization in aqueous media, thermoresponsiveness and biocompatibility

Dendritic poly(benzyl ether)-b-poly(N-vinylcaprolactam) block copolymers: Self-organization in aqueous media, thermoresponsiveness and biocompatibility
Fuxi He, Yangyang Qian, Dan You, Gang Tang, Minqi Hu, Yunmei Bi
Four generations of new amphiphilic thermoresponsive linear-dendritic block copolymers (LDBCs) with a linear poly(N-vinylcaprolactam) (PNVCL) block and a dendritic poly(benzyl ether) block are synthesized by atom transfer radical polymerization (ATRP) of N-vinylcaprolactam (NVCL) using dendritic poly(benzyl ether) chlorides as initiators. The copolymers have been characterized by 1H NMR, FTIR, and GPC showing controlled molecular weight and narrow molecular weight distribution (PDI ≤ 1.25). Their self-organization in aqueous media and thermoresponsive property are highly dependent on the generation of dendritic poly(benzyl ether) block. It is observed for the LDBCs that the self-assembled morphology changes from irregularly spherical micelles, vesicles, rod-like large compound vesicles (LCVs), to the coexistence of spherical micelles and rod-like LCVs, as the generation of the dendritic poly(benzyl ether) increases. The results of a cytotoxicity study using an MTT assay method with L929 cells show that the LDBCs are biocompatible. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 Novel amphiphilic thermoresponsive linear-dendritic block copolymers composed of a linear poly(N-vinylcaprolactam) (PNVCL) chain and the first to the fourth generations of a Fréchet-type polyether have been synthesized. Their self-assembly behavior and thermoresponsive property are affected by the generation of the dendritic poly(benzyl ethers) block. They are proven to be nontoxic to L929 cells.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/pola.28897

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