Organic Letters
Organic Letters
5 years ago

BODIPY–Au(I): A Photosensitizer for Singlet Oxygen Generation and Photodynamic Therapy

BODIPY–Au(I): A Photosensitizer for Singlet Oxygen Generation and Photodynamic Therapy
Mustafa Emrullahoğlu, Suay Dartar, Melike Sayar, Muhammed Üçüncü, Erman Karakuş, Eylem Kurulgan Demirci
Upon complexation with Au(I), a photoinactive BODIPY derivative was transformed into a highly photoactive triplet sensitizer. Along with high efficiency in singlet oxygen generation (ΦΔ = 0.84), the new BODIPY–Au(I) skeleton showed excellent photocytotoxic activity against cancer cell lines (EC50 = 2.5 nM).

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00791

DOI: 10.1021/acs.orglett.7b00791

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