3 years ago

Selective ion binding and transport by membrane proteins – A computational perspective

Selective ion binding and transport by membrane proteins – A computational perspective
Inorganic ions are critical for cellular function and require an efficient mechanism of transport through the cellular membrane. Most often the transport of ions occurs through proteins known as ion channels and transporters. Ion binding and permeation through these proteins is a complicated process that is still under investigation with a wide range of experimental and theoretical methods. Here we present an overview of some of the competing theories of ion transport with special emphasis on the theoretical methods used for the elucidation of the energetics of ion selectivity, coordination and permeation. A large part of the review is dedicated to potassium and sodium channels and transporters, which are among the best studied biological transport systems and provide a frame of reference for all other ion-protein interactions. In addition, we summarize the computational work done on the transport of several other small inorganic ions (calcium, magnesium, chloride, inorganic phosphate). Our aim is to provide a general picture of the current state of knowledge on biological ion-transport phenomena and to evaluate the capabilities of modern computational methods when applied to ion transport. We also strive to draw attention to some underdeveloped areas of ion transport that require further investigation.

Publisher URL: www.sciencedirect.com/science

DOI: S0010854516305033

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.