Organic Letters
Organic Letters
5 years ago

[3 + 3] Cycloaddition of in Situ Formed Azaoxyallyl Cations with 2-Alkenylindoles: An Approach to Tetrahydro-β-carbolinones

[3 + 3] Cycloaddition of in Situ Formed Azaoxyallyl Cations with 2-Alkenylindoles: An Approach to Tetrahydro-β-carbolinones
Aijun Lin, Xiaoying Xu, Kaifan Zhang, Yue Huang, Jiuan Zheng, Hequan Yao
A novel [3 + 3] cycloaddition between in situ formed azaoxyallyl cations and 2-alkenylindoles has been developed. This concise method allows the efficient construction of a series of tetrahydro-β-carbolinones in good yields under mild conditions. Gram-scale experiments and further derivatization of tetrahydro-β-carbolinones highlighted the potential utility of our method.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00914

DOI: 10.1021/acs.orglett.7b00914

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