Inorganic Chemistry
Inorganic Chemistry
5 years ago

Undervalued N3 Coordination Revealed in the Cisplatin Complex with 2′-Deoxyadenosine-5′-monophosphate by a Combined IRMPD and Theoretical Study

Undervalued N3 Coordination Revealed in the Cisplatin Complex with 2′-Deoxyadenosine-5′-monophosphate by a Combined IRMPD and Theoretical Study
Barbara Chiavarino, Maria Elisa Crestoni, Jean-Yves Salpin, Debora Scuderi, Simonetta Fornarini
The gas-phase structures of the species obtained by the reaction of cisplatin and 2′-deoxyadenosine-5′-monophosphate (5′-dAMP) are investigated by infrared multiple photon dissociation (IRMPD) action spectroscopy combined with quantum-chemical calculations. IRMPD kinetic experiments indicate that the most abundant component in the sampled cis-[PtCl(NH3)2(5′-dAMP)]+ ionic population is the isomer platinated at the N3 position of adenine, in spite of it being the less stable one among the potential candidates.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b00570

DOI: 10.1021/acs.inorgchem.7b00570

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