3 years ago

Rhodium(III)-Catalyzed C–H Activation/Heterocyclization as a Macrocyclization Strategy. Synthesis of Macrocyclic Pyridones

Rhodium(III)-Catalyzed C–H Activation/Heterocyclization as a Macrocyclization Strategy. Synthesis of Macrocyclic Pyridones
Janine Cossy, Gino Ricci, Marc-Antoine Perrin, Jean-Philippe Krieger, Dominique Lesuisse, Christophe Meyer
Structurally diverse macrocyclic pyridones can be efficiently synthesized by a rhodium(III)-catalyzed C–H activation/heterocyclization of ω-alkynyl α-substituted acrylic hydroxamates. The use of a O-pivaloyl hydroxamate as directing group was crucial to achieve efficient catalyst turnover in a redox-neutral process.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01051

DOI: 10.1021/acs.orglett.7b01051

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