Dalton Transactions
Dalton Transactions
5 years ago

Speciation in human blood of Metvan, a vanadium based potential anti-tumor drug

Speciation in human blood of Metvan, a vanadium based potential anti-tumor drug
Linda Biro, Giovanni Micera, Valeria Ugone, Peter Buglyo, Eugenio Garribba, Daniele Sanna
The speciation of the anti-tumor drug Metvan, [VIVO(Me2phen)2(SO4)], suggested that for c(V) > 50 [small mu ]M, [VO(Me2phen)(citrH-1)]2- and the ternary complexes VO-Me2phen-Protein should be the major species at pH 7.4, while for c(V) < 10 [small mu ]M, (VO)(hTf) is formed, Me2phen is lost and the conversion of VIVO to VVO/VVO2 may occur.

Publisher URL: http://feeds.rsc.org/~r/rss/DT/~3/tYfxjlaOfG8/C7DT00943G

DOI: 2017/DT/C7DT00943G

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