3 years ago

Highly selective peroxisome proliferator-activated receptor δ (PPAR δ) modulator demonstrates improved safety profile compared to GW501516

Highly selective peroxisome proliferator-activated receptor δ (PPAR δ) modulator demonstrates improved safety profile compared to GW501516
Compound 1 regulates significantly fewer genes than the PPAR δ modulator, GW501516. Both compounds are efficacious in a thermal injury model of muscle regeneration. The restricted gene profile of 1 relative to GW501516 suggests that 1 may be pharmacoequivalent to GW501516 with fewer PPAR-related safety concerns.

Publisher URL: www.sciencedirect.com/science

DOI: S0960894X17310818

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