Journal of Inorganic Biochemistry
Journal of Inorganic Biochemistry
5 years ago

Effect of tunable redox behavior of bis chelate substituted 1,10-phenantroline Cu(II) complexes on its reaction with superoxide anion in DMSO. Toward a simple criterion to identify a SOD-like mechanism

Effect of tunable redox behavior of bis chelate substituted 1,10-phenantroline Cu(II) complexes on its reaction with superoxide anion in DMSO. Toward a simple criterion to identify a SOD-like mechanism
In this work we report a series of Cu(II) complexes [Cu(NN)2(X)]+, (NN=substituted 1,10-phenanthroline derivatives and X=Cl− or NO3 −), with tunable E1/2 for electrochemical reduction [CuII(NN)2(X)]+ +1e− ⇌[CuI(NN)2]+X−. The disproportion of O2 •− Cu(II)+1e→Cu(I) was explored in presence of the electro-generated species [CuI(NN)2]+ using cyclic voltammetry in a non-aqueous media, arising a new simple method to propose a SOD-like mechanism, which can be used as a quick guide test for a compound, before being proven in biological assays. It was found that complexes with high negative half wave potential values (E1/2) for Cu(II)/Cu(I) couple shown an increment of current for oxygen reduction, related to the capability of the disproportion of this reactive oxygen species.

Publisher URL: www.sciencedirect.com/science

DOI: S0162013417300478

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.