3 years ago

Vms1 Relieves a Mitochondrial Import Chokehold

Vms1 Relieves a Mitochondrial Import Chokehold
Cole M. Haynes, Lilian Lamech

Ribosome stalling results in the production of truncated proteins that can cause proteotoxic stress if not efficiently degraded. A recent paper by Izawa et al. (2017) identifies Vms1 as a key player in the regulation of ribosome quality control specifically on mitochondria-localized ribosomes, ultimately preventing protein aggregate accumulation within mitochondria.

Publisher URL: http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30865-1

DOI: 10.1016/j.devcel.2017.10.022

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