3 years ago

Astrocytes Supply Presynaptic Terminals with a Sweet Incentive to Make Connections

Astrocytes Supply Presynaptic Terminals with a Sweet Incentive to Make Connections
Joris de Wit, Giuseppe Condomitti

Glial cells shape neural circuits by secreting cues that contribute to the spatiotemporal control of connectivity. A new study in Neuron from Farhy-Tselnicker et al. (2017) shows that the astrocyte-secreted heparan sulfate proteoglycan GPC4 acts on presynaptic terminals to indirectly regulate AMPA receptor clustering and active synapse formation.

Publisher URL: http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30861-4

DOI: 10.1016/j.devcel.2017.10.018

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