3 years ago

Neural Lineage Progression Controlled by a Temporal Proliferation Program

Neural Lineage Progression Controlled by a Temporal Proliferation Program
Erika Gunnar, Stefan Thor, Helen Ekman, Carolin Jonsson, Shahrzad Bahrampour


Great progress has been made in identifying transcriptional programs that establish stem cell identity. In contrast, we have limited insight into how these programs are down-graded in a timely manner to halt proliferation and allow for cellular differentiation. Drosophila embryonic neuroblasts undergo such a temporal progression, initially dividing to bud off daughters that divide once (type I), then switching to generating non-dividing daughters (type 0), and finally exiting the cell cycle. We identify six early transcription factors that drive neuroblast and type I daughter proliferation. Early factors are gradually replaced by three late factors, acting to trigger the type I→0 daughter proliferation switch and eventually to stop neuroblasts. Early and late factors regulate each other and four key cell-cycle genes, providing a logical genetic pathway for these transitions. The identification of this extensive driver-stopper temporal program controlling neuroblast lineage progression may have implications for studies in many other systems.

Publisher URL: http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30817-1

DOI: 10.1016/j.devcel.2017.10.004

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