3 years ago

Core–Satellite Polydopamine–Gadolinium-Metallofullerene Nanotheranostics for Multimodal Imaging Guided Combination Cancer Therapy

Core–Satellite Polydopamine–Gadolinium-Metallofullerene Nanotheranostics for Multimodal Imaging Guided Combination Cancer Therapy
Orit Jacobson, Ruiliang Bai, Sheng Wang, Peng Huang, Xiao Fu, Zhantong Wang, Nan Lu, Siping Chen, Xiaoyuan Chen, Tianfu Wang, Yijing Liu, Wenpei Fan, Zijian Zhou, Junle Qu, Jing Lin
Integration of magnetic resonance imaging (MRI) and other imaging modalities is promising to furnish complementary information for accurate cancer diagnosis and imaging-guided therapy. However, most gadolinium (Gd)–chelator MR contrast agents are limited by their relatively low relaxivity and high risk of released-Gd-ions-associated toxicity. Herein, a radionuclide-64Cu-labeled doxorubicin-loaded polydopamine (PDA)–gadolinium-metallofullerene core–satellite nanotheranostic agent (denoted as CDPGM) is developed for MR/photoacoustic (PA)/positron emission tomography (PET) multimodal imaging-guided combination cancer therapy. In this system, the near-infrared (NIR)-absorbing PDA acts as a platform for the assembly of different moieties; Gd3N@C80, a kind of gadolinium metallofullerene with three Gd ions in one carbon cage, acts as a satellite anchoring on the surface of PDA. The as-prepared CDPGM NPs show good biocompatibility, strong NIR absorption, high relaxivity (r 1 = 14.06 mM−1 s−1), low risk of release of Gd ions, and NIR-triggered drug release. In vivo MR/PA/PET multimodal imaging confirms effective tumor accumulation of the CDPGM NPs. Moreover, upon NIR laser irradiation, the tumor is completely eliminated with combined chemo-photothermal therapy. These results suggest that the CDPGM NPs hold great promise for cancer theranostics. A versatile cancer theranostic agent, with good biocompatibility, high relaxivity, low risk of release of Gd ions, and near-infrared-triggered drug release, is developed based on core–satellite polydopamine–gadolinium metallofullerene, for magnetic resonance/photoacoustic/positron emission tomography multimodal imaging and chemo-photothermal combination therapy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adma.201701013

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