Advanced Materials
Advanced Materials
5 years ago

A Microfluidic Ion Pump for In Vivo Drug Delivery

A Microfluidic Ion Pump for In Vivo Drug Delivery
Vincenzo F. Curto, Ilke Uguz, Róisín M. Owens, Christopher M. Proctor, George G. Malliaras, Magali Ferro, Sahika Inal, Anna-Maria Pappa, Dion Khodagholy, Mary J. Donahue
Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems. A microfluidic ion pump is developed, which is capable of delivering a drug without a solvent. In vitro characterization shows low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. Cortical delivery in an animal model shows that this device represents a significant step forward toward the development of implantable drug-delivery systems.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adma.201701217

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