4 years ago

Digest: Unpacking fitness effects of spontaneous mutations

Sonia Singhal
New biological variation originates from mutations, so understanding their effects—and how those effects vary with environment or genetic background—is critical to evolutionary studies. Kraemer et al. (2017) sequenced and measured the fitness of Chlamydomonas reinhardtii lineages that had experienced minimal selection. They found that mutations in these lineages had a small average deleterious effect attributable to mutations in coding regions, and average mutational effects varied depending on the ancestor's genotype. This article is protected by copyright. All rights reserved

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/evo.13388

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