3 years ago

Radiosynthesis and biodistribution of 99m Tc-Sulfamethoxazole: a novel molecule for in-vivo infection imaging

Uğur Avcıbaşı, Özge Uyaroğlu, Elgin Uluer Türköz, Fikriye Gül Gümüşer, Volkan Demir, Perihan Ünak, Buket Ateş, Hasan Demiroğlu, Yasemin Parlak, Gökçen Topal

Abstract

The aim of this study was to prepare 99mTc-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with 99mTc and its biological efficacy as a potential radio tracer for Staphylococcus aureus infection was investigated in bacterially infected Albino Wistar rats. The radiolabeling yield was found to be 95 ± 3.07% and remained constant at more than 93 ± 0.1% even in serum for 240 min after radiolabeling. 99mTc-Sulfamethoxazole prepared with high yield localized well in the bacterially infected muscle of the rats. 99mTc-Sulfamethoxazole may be developed as a radiopharmaceutical agent to distinguish infection from inflammation by nuclear imaging.

Publisher URL: https://link.springer.com/article/10.1007/s00044-017-2009-4

DOI: 10.1007/s00044-017-2009-4

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