4 years ago

Hyperpolarization of Amino Acid Derivatives in Water for Biological Applications.

S. Wagner, S. Glöggler, Louis-S. Bouchard

We report on the successful synthesis and hyperpolarization of N unprotected {\alpha} amino acid ethyl acrylate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4$\pm$1% $^{13}$C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.

Publisher URL: http://arxiv.org/abs/1711.01553

DOI: arXiv:1711.01553v1

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