Organic Letters
Organic Letters
5 years ago

Fe/Cu-Mediated One-Pot Ketone Synthesis

Fe/Cu-Mediated One-Pot Ketone Synthesis
Vaddela Sudheer Babu, Vemula Praveen Kumar, Yoshito Kishi, Kenzo Yahata
An Fe/Cu-mediated one-pot ketone synthesis was reported. Unlike Ni- and Pd-mediated one-pot ketone syntheses, the reported Fe/Cu-mediated method allowed selective activation and coupling of alkyl iodides over vinyl iodides. The newly developed one-pot ketone synthesis was applied to a synthesis of vinyl iodide/ketone 13, the left half of halichondrin B, as well as vinyl iodide/ketone 8a, the C20–C26 building block of halichondrins.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01128

DOI: 10.1021/acs.orglett.7b01128

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