Organic Letters
Organic Letters
5 years ago

Amine-Controlled Divergent Reaction: Iminolactonization and Olefination in the Presence of a Cu(I) Catalyst

Amine-Controlled Divergent Reaction: Iminolactonization and Olefination in the Presence of a Cu(I) Catalyst
Kohei Itonaga, Norihiro Yamaguchi, Michinori Sumimoto, Takashi Nishikata
α-Bromoamides and styrenes underwent iminolactonization reactions (carbooxygenation), in which simultaneous C–C and C–O formation occurred in the presence of a copper catalyst with triethylamine as the base. Conversely, olefination reactions occurred in the presence of a Cu catalyst with piperidine as the base. The selectivities in those reactions were very high.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01020

DOI: 10.1021/acs.orglett.7b01020

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