3 years ago

Meta-analysis of associations between maternal breast cancer and the risk of adverse delivery outcomes

Liqi Yang, Chenyu Sun, Yile Wu, Xiuxiu Ding
Background Research into the effects of breast cancer on delivery outcomes has generated inconsistent findings. Objectives To pool data from existing observational studies of the effect of breast cancer on preterm delivery and low delivery weight. Search strategy A systematic literature search of PubMed, Embase, and Web of Science databases using keywords including, “breast cancer” and “birth outcome” up to March 7, 2017, was performed. Selection criteria Observational studies of the effect of breast cancer on delivery outcomes were included. Data collection and analysis: Articles were reviewed independently by two authors and data were extracted. Risk ratios and 95% confidence intervals were calculated. Main results Preterm delivery data were included from seven studies including 6 687 579 patients and low delivery weight data were retrieved from five studies including 6 687 103 patients. Maternal breast cancer was associated with an increased risk of preterm delivery (pooled risk ratio 1.82, 95% confidence interval 1.44–2.30) and low delivery weight (pooled risk ratio 1.41, 95% confidence interval 1.15–1.74). No publication bias was detected in the meta-analysis. Conclusions The present meta-analysis demonstrated that maternal breast cancer was associated with increased risk of preterm delivery and low delivery weight. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ijgo.12375

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