3 years ago

Iodine-Catalyzed Facile Approach to Sulfones Employing TosMIC as a Sulfonylating Agent

Iodine-Catalyzed Facile Approach to Sulfones Employing TosMIC as a Sulfonylating Agent
Radha Krishna Palakodety, Lakshmi Prapurna Yallapragada, Lingaswamy Kadari
A novel iodine-catalyzed functionalization of a variety of olefins and alkynes and direct decarboxylative functionalization of cinnamic and propiolic acids with TosMIC to provide access to various vinyl, allyl, and β-iodo vinylsulfones is described. This simple, efficient, and environmentally benign approach employing inexpensive molecular iodine as a catalyst demonstrates a versatile protocol for the synthesis of highly valuable sulfones, rendering it attractive to both synthetic and medicinal chemistry.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00896

DOI: 10.1021/acs.orglett.7b00896

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