3 years ago

Second-trimester levels of fetoplacental hormones among women with placenta accreta spectrum disorders

Eric Jauniaux, Marina Pekar-Zlotin, Yaakov Melcer, Ron Maymon
Human chorionic gonadotropin (hCG) and its free β-subunit (β-hCG) are exclusively synthesized by the villous trophoblast. α-Fetoprotein (AFP) is synthesized by the secondary yolk sac and fetal liver. Levels of both hormones differ between women with placenta accreta spectrum (PAS) disorders and those with non-accreta previa.1,2 Second-trimester maternal serum levels of AFP are increased,1 and first-trimester serum β-hCG is decreased in women with PAS,2 compared with those with non-accreta placenta previa. An increased level of cell-free β-hCG mRNA has also been found in the plasma of women with PAS disorder.3 The aim of the present study was to further assess the association between levels of serum markers measured as part of the triple test in the second trimester (hCG, AFP, and estriol) and the prenatal diagnosis of PAS disorders. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ijgo.12352

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