3 years ago

Meta-analysis of the association of maternal smoking and passive smoking during pregnancy with neural tube defects

Xin Meng, Wenhou Duan, Chongqi Jia, Yanxin Sun
Background It is unclear whether the incidence of neural tube defects (NTDs) is greater with maternal smoking or with passive smoking during pregnancy. Objectives To compare the effects of smoking and passive smoking during pregnancy on the risk of NTDs. Search strategy English and Chinese databases were searched for relevant papers published before March 2017, using search terms including “smoking” and “NTD.” Selection criteria Case–control and cohort studies on the aforementioned association were included. Data collection and analysis Two authors independently extracted the original data. Meta-analyses were performed to assess the risks associated with smoking and passive smoking, followed by a comparison of the two pooled effect estimates. The I2 statistic was used to examine between-study heterogeneity. Main results The final analysis included 23 articles representing 33 studies. The pooled odds ratio (OR) and 95% confidence interval (CI) for the risk of NTDs was 1.052 (0.907–1.220) with smoking and 1.898 (1.557–2.313) with passive smoking. Comparison of these ORs indicated that the risk of NTDs was higher with passive smoking than with smoking (OR 1.804, 95% CI 1.409–2.309). Conclusions Compared with smoking, exposure to passive smoking during pregnancy carries a higher risk of having infants with NTDs.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ijgo.12334

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