3 years ago

The Corticotropin Releasing Factor Binding Protein: a strange case of Dr. Jekyll and Mr. Hyde in the stress system?

The corticotropin releasing factor (CRF) exerts its effects by acting on its receptors and on the binding protein (CRFBP). Extensive literature suggests a role of CRF in alcohol use disorder (AUD). Less is known on the specific role, if any, of CRFBP in AUD. In this review, we summarize recent interdisciplinary efforts towards identifying the contribution of CRFBP in mediating CRF activation. The role of CRFBP in alcohol-related behaviors has been evaluated with the ultimate goal of designing effective novel therapeutic strategies for AUD. A series of in vitro, in vivo, ex vivo and genetic studies presented here provide initial evidence that CRFBP may possess both inhibitory and excitatory roles and support the original hypothesis that it represents a novel pharmacological target for the treatment of AUD. This report summarizes the proceedings of one of the talks at the Young Investigator Award symposium at the Alcoholism and Stress: A Framework for Future Treatment Strategies Conference, Volterra, Italy.

Publisher URL: www.sciencedirect.com/science

DOI: S074183291730873X

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