3 years ago
Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2
The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C -geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C -geranylated flavone, paucatalinone C (1 ) and five known C -geranylated flavanones (2 –6 ) were isolated. In addition, a total of 34 C -geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH2 Cl2 extract of P. catalpifolia . Futhermore, anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by H2 O2 . Phytochemical results indicated that P. catalpifolia was a natural resource of abundant C -geranylated flavonoids. Diplacone (3 ) and paucatalinone A (5 ) were the potent anti-aging agents in the premature senescent 2BS cells induced by H2 O2 and the C-geranyl substituent may be an important factor because of its lipophilic character.
Publisher URL: www.sciencedirect.com/science
DOI: S1875536417300596
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