3 years ago

Effect of sufentanil on bispectral index in the elderly

C. Czarnetzki, M. R. Tramèr, C. Lysakowski, L. Dumont, N. Elia, T. Valence
We examined the impact of adding sufentanil during anaesthesia induction with propofol on bispectral index values in elderly patients (≥ 65 years). Patients were randomly assigned to receive a target-controlled sufentanil infusion (effect-site concentration of 0.3 ng.ml−1) or matching placebo, followed by a target-controlled propofol induction (initial effect-site concentration of 0.5 μg.ml−1; step-wise increase of 0.5 μg.ml−1) until loss of consciousness defined as an Observer's Assessment of Alertness/Sedation score < 2. Seventy-one patients (sufentanil 35, placebo 36) completed the study. Mean (SD) age was 72.3 (5.8) years; 41% were women. At loss of consciousness, mean (SD) bispectral index value was 75.0 (8.6) with sufentanil and 70.0 (8.0) with placebo; mean difference −5.0 (95% confidence interval −8.9 to −1.1), p = 0.013. Post-hoc analyses suggest that the difference was significant in men only (mean difference −7.3 (−11.8 to −2.6), p = 0.003). Sufentanil co-induction with propofol results in higher bispectral index values at loss of consciousness in elderly patients.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/anae.14102

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