3 years ago

Sulfur-Directed Ligand-Free C–H Borylation by Iridium Catalysis

Sulfur-Directed Ligand-Free C–H Borylation by Iridium Catalysis
Guanghui Wang, Pengfei Li, Li Liu, Jiao Jiao
An iridium-catalyzed ortho C–H borylation reaction directed by cyclic dithioacetal moiety is disclosed. A series of borylation products were obtained in moderate to good yields under mild conditions in exclusive mono- and ortho-regioselectivity. Thus, the 1,3-dithiane or 1,3-dithiolane group serves as a remarkable effective directing group for C–H borylation without any ligand assistance. The further transformations of the borylation products are also carried out to change boryl group to other functional groups.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b03008

DOI: 10.1021/acs.orglett.7b03008

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