3 years ago

Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group

Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group
Tsubasa Nishimura, Hiroshi Shinokubo, Yoshitsugu Shiro, Hiroshi Sugimoto, Hiromu Uehara, Yoshihiro Miyake, Yoshihito Watanabe, Osami Shoji, Yuma Shisaka
The heme acquisition protein HasA from P. aeruginosa can accommodate iron(III)-5,15-diphenylporphyrin and several derivatives, despite the fact that they have bulky substituents at the meso position of the porphyrin. In their Communication (DOI: 10.1002/anie.201707212) O. Shoji and co-workers present crystal structures of these artificial HasAs, and show that the growth inhibition effect against P. aeruginosa differs depending on the structure of the metal complex captured.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201710879

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