3 years ago

The Relationship of Collagen Structural and Compositional Heterogeneity to Tissue Mechanical Properties: A Chemical Perspective

The Relationship of Collagen Structural and Compositional Heterogeneity to Tissue Mechanical Properties: A Chemical Perspective
Mark M. Banaszak Holl, Junjie Chen, Jinhee Kim, Isabel D. Colón-Bernal, Taeyong Ahn
Collagen is the primary protein component in mammalian connective tissues. Over the last 20 years, evidence has mounted that collagen matrices exhibit substantial heterogeneity in their hierarchical structures and that this heterogeneity plays important roles in both structure and function. Herein, an overview of studies addressing the nanoscale compositional and structural heterogeneity is provided and connected to work exploring the mechanical implications for a number of tissues.

Publisher URL: http://dx.doi.org/10.1021/acsnano.7b06826

DOI: 10.1021/acsnano.7b06826

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