3 years ago

Identification of Functional Peptide Sequences to Lead the Design of Precision Polymers

Identification of Functional Peptide Sequences to Lead the Design of Precision Polymers
Hans G. Börner, Niels ten Brummelhuis, Patrick Wilke
Peptide sciences developed dramatically as a result of routine use of solid-phase peptide synthesis and nowadays offer a rich set of well-established strategies to design and identify functional peptide sequences for advanced applications in materials sciences. Appropriate sequences for a wide range of interesting material targets, ranging from molecules to materials surfaces and internal interfaces, can be selected via combinatorial means, and sequence specificities within the resulting peptide–target interactions can be routinely investigated. Based on this understanding, macromolecular sciences can define new polymer structures that meet required functionalities or functional sequences with fully synthetic, nonpeptidic precision polymers to endeavor toward information-based design of next-generation, purpose-adapted macromolecules. In this review, methods for the selection of functional amino acid sequences as well as methods to gain insight into the sequence–function relationship of these peptides are discussed. This knowledge can not only be used for the design of functional peptide-based materials but also to set useful goals for the preparation of nonpeptidic (sequence-defined) synthetic polymers.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/marc.201700632

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